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M represents the rabbit pyrogen test dose or the most human dose for every kilogram that could be administered in an individual a single hour interval, whichever is larger sized. If an item is labeled for intrathecal injection, then K is 0.two EU/kg. However, you will discover five h2o solutions (Beforehand mentioned) which, because of the big volumes which might be administered and absence of dose limitation, have unique endotoxin limits for each ml.??sporting activities bettors.
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Other fewer generally appropriate solutions contain ethylene oxide treatment method and irradiation. It has been shown that reductions of about 80% within the pyrogenicity of E. coli endotoxin in dialyzers have happened immediately after exposure to ethylene oxide.
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